Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 3/20 | 0.49 |
| ▸ | AKT2 | P31751 | 4/20 | 0.43 |
| ▸ | PBK | Q96KB5 | 2/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | NUDT1 | P36639 | 5/20 | 0.38 |
| ▸ | CCNK | O75909 | 3/20 | 0.38 |
| ▸ | CDK12 | Q9NYV4 | 3/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.38 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18602396 | 0.83 | PRKCI (0.45) | PRKCIAKT2PBKNUDT1CCNK | |
| SCHEMBL18602200 | 0.82 | PRKCI (0.55) | PRKCIAKT2PBKNUDT1CCNK | |
| SCHEMBL101234 | 0.82 | PRKCI (0.44) | PRKCIAKT2NUDT1CCNKCDK12 | |
| SCHEMBL101300 | 0.82 | PRKCI (0.44) | PRKCIAKT2PBKNUDT1CCNK | |
| SCHEMBL18602146 | 0.80 | PRKCI (0.46) | PRKCIAKT2NUDT1CCNKCDK12 | |
| SCHEMBL100453 | 0.80 | PRKCI (0.59) | PRKCIAKT2PBKNUDT1CCNK | |
| SCHEMBL29540813 | 0.80 | PRKCI (0.59) | PRKCIAKT2PBKNUDT1CCNK | |
| SCHEMBL12330233 | 0.80 | PRKCI (0.52) | PRKCIAKT2PBKNUDT1CCNK | |
| SCHEMBL100065 | 0.78 | PRKCI (0.47) | PRKCIAKT2PBKNUDT1CCNK | |
| SCHEMBL29541013 | 0.78 | PRKCI (0.47) | PRKCIAKT2PBKNUDT1CCNK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2474545-A1 | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors | Incyte Corporation (US) | 2012-07-11 | — | — | EP | disclosed |