Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 14/20 | 0.70 |
| ▸ | MAOA | P21397 | 5/20 | 0.48 |
| ▸ | MAOB | P27338 | 5/20 | 0.48 |
| ▸ | PRKCI | P41743 | 1/20 | 0.48 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.45 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10190625 | 0.84 | GRM5 (0.70) | GRM5MAOAMAOBPRKCICYP2A6 | |
| SCHEMBL10190633 | 0.84 | GRM5 (0.70) | GRM5MAOAMAOBPRKCICYP2A6 | |
| SCHEMBL10190614 | 0.83 | GRM5 (1.00) | GRM5MAOAMAOBPRKCICYP2A6 | |
| SCHEMBL10190637 | 0.81 | GRM5 (0.75) | GRM5MAOAMAOBPRKCICYP2A6 | |
| SCHEMBL10190642 | 0.81 | GRM5 (0.74) | GRM5MAOAMAOBPRKCICYP2A6 | |
| SCHEMBL504524 | 0.79 | GRM5 (1.00) | GRM5 | |
| SCHEMBL24570702 | 0.76 | GRM5 (0.66) | GRM5HSD17B1 | |
| SCHEMBL29739204 | 0.76 | GRM5 (0.66) | GRM5HSD17B1 | |
| SCHEMBL10190636 | 0.76 | GRM5 (0.75) | GRM5MAOAMAOBPRKCICYP2A6 | |
| SCHEMBL10190634 | 0.76 | GRM5 (0.75) | GRM5MAOAMAOBPRKCICYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120028955-A1 | BICYCLIC MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME | VANDERBILT UNIVERSITY | 2012-02-02 | — | — | US | disclosed |
| US-20120028956-A1 | BICYCLIC MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME | VANDERBILT UNIVERSITY | 2012-02-02 | — | — | US | disclosed |
| US-8034806-B2 | Bicyclic mGluR5 positive allosteric modulators and methods of making and using same | VANDERBILT UNIVERSITY (US) | 2011-10-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028955-A1 | BICYCLIC MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME | GRM5, GRIK5, GRM1 | GRM5 1/4885MAOA 3858/4885MAOB 4108/4885 |
| US-20120028956-A1 | BICYCLIC MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME | GRM5, GRIK5, GRM1 | GRM5 1/4885MAOA 3858/4885MAOB 4108/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.