Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 14/20 | 0.78 |
| ▸ | PARP10 | Q53GL7 | 6/20 | 0.69 |
| ▸ | PARP11 | Q9NR21 | 5/20 | 0.69 |
| ▸ | PARP1 | P09874 | 2/20 | 0.56 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL504553 | 0.87 | GRM5 (1.00) | GRM5PARP10PARP11PARP1 | |
| SCHEMBL504253 | 0.87 | GRM5 (1.00) | GRM5PARP10PARP11PARP1PDPK1 | |
| SCHEMBL504523 | 0.85 | GRM5 (0.78) | GRM5PARP10PARP11PARP1PDPK1 | |
| SCHEMBL504325 | 0.85 | GRM5 (1.00) | GRM5PARP10PARP11PARP1 | |
| SCHEMBL504324 | 0.85 | GRM5 (0.76) | GRM5PARP10PARP11PARP1PDPK1 | |
| SCHEMBL504342 | 0.85 | GRM5 (0.79) | GRM5PARP10PARP11 | |
| SCHEMBL505174 | 0.85 | GRM5 (0.71) | GRM5PARP10PARP11PARP1PDPK1 | |
| SCHEMBL504652 | 0.83 | GRM5 (1.00) | GRM5PARP10PARP11 | |
| SCHEMBL279903 | 0.82 | PARP10 (1.00) | GRM5PARP10PARP11PARP1PDPK1 | |
| SCHEMBL29978302 | 0.82 | PARP10 (1.00) | GRM5PARP10PARP11PARP1PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120028956-A1 | BICYCLIC MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME | VANDERBILT UNIVERSITY | 2012-02-02 | — | — | US | disclosed |
| US-20120028955-A1 | BICYCLIC MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME | VANDERBILT UNIVERSITY | 2012-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028955-A1 | BICYCLIC MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME | GRM5, GRIK5, GRM1 | GRM5 1/4885PARP10 2146/4885PARP11 3085/4885 |
| US-20120028956-A1 | BICYCLIC MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME | GRM5, GRIK5, GRM1 | GRM5 1/4885PARP10 2146/4885PARP11 3085/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.