Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 8/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | TYK2 | P29597 | 4/20 | 0.52 |
| ▸ | JAK1 | P23458 | 3/20 | 0.52 |
| ▸ | JAK3 | P52333 | 3/20 | 0.52 |
| ▸ | EPHB3 | P54753 | 5/20 | 0.48 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL407094 | 0.89 | JAK2 (0.69) | JAK2CYP1A2TYK2JAK1JAK3 | |
| SCHEMBL403229 | 0.86 | JAK2 (0.54) | JAK2CYP1A2TYK2JAK1JAK3 | |
| SCHEMBL402297 | 0.84 | JAK2 (0.58) | JAK2CYP1A2TYK2JAK1JAK3 | |
| SCHEMBL405612 | 0.80 | JAK2 (0.79) | JAK2TYK2JAK1JAK3EPHB3 | |
| SCHEMBL18049730 | 0.77 | IRAK4 (0.59) | JAK2CYP1A2EPHB3IRAK4RIPK2 | |
| SCHEMBL401483 | 0.75 | JAK2 (0.63) | JAK2CYP1A2TYK2JAK1JAK3 | |
| SCHEMBL405744 | 0.72 | JAK2 (0.71) | JAK2CYP1A2TYK2JAK1JAK3 | |
| SCHEMBL402529 | 0.72 | JAK2 (1.00) | JAK2CYP1A2TYK2JAK1JAK3 | |
| SCHEMBL405277 | 0.72 | JAK2 (0.82) | JAK2TYK2JAK1JAK3IRAK4 | |
| SCHEMBL404932 | 0.72 | JAK2 (0.83) | JAK2TYK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160244456-A1 | PYRAZOLOPYRIMIDINE JAK INHIBITOR COMPOUNDS AND METHODS | GENENTECH, INC. (US) | 2016-08-25 | — | — | US | disclosed |
| US-20140107099-A1 | PYRAZOLOPYRIMIDINE JAK INHIBITOR COMPOUNDS AND METHODS | GENENTECH, INC. (US) | 2014-04-17 | — | — | US | disclosed |
| US-8637526-B2 | Pyrazolopyrimidine JAK inhibitor compounds and methods | GENENTECH, INC. (US) | 2014-01-28 | — | — | US | disclosed |
| US-20120022043-A1 | PYRAZOLOPYRIMIDINE JAK INHIBITOR COMPOUNDS AND METHODS | GENENTECH, INC. (US) | 2012-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120022043-A1 | PYRAZOLOPYRIMIDINE JAK INHIBITOR COMPOUNDS AND METHODS | JAK2, JAK1, JAK3 | JAK2 1/4885CYP1A2 575/4885TYK2 18/4885 |
| US-20140107099-A1 | PYRAZOLOPYRIMIDINE JAK INHIBITOR COMPOUNDS AND METHODS | JAK2, JAK1, JAK3 | JAK2 1/4885CYP1A2 575/4885TYK2 18/4885 |
| US-20160244456-A1 | PYRAZOLOPYRIMIDINE JAK INHIBITOR COMPOUNDS AND METHODS | JAK2, JAK1, JAK3 | JAK2 1/4885CYP1A2 575/4885TYK2 18/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.