Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.50 |
| ▸ | SYK | P43405 | 1/20 | 0.48 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.47 |
| ▸ | CFD | P00746 | 1/20 | 0.47 |
| ▸ | NEK2 | P51955 | 3/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | MERTK | Q12866 | 8/20 | 0.45 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | AXL | P30530 | 6/20 | 0.43 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL168549 | 0.82 | LRRK2 (0.61) | LRRK2 | |
| SCHEMBL176152 | 0.82 | LRRK2 (0.76) | LRRK2METMCL1 | |
| SCHEMBL168867 | 0.78 | LRRK2 (0.76) | LRRK2METMCL1 | |
| SCHEMBL166527 | 0.78 | LRRK2 (0.61) | LRRK2 | |
| SCHEMBL168617 | 0.76 | LRRK2 (0.49) | LRRK2CFDNEK2AURKAMERTK | |
| SCHEMBL24731500 | 0.74 | PRMT5 (0.52) | LRRK2CFDMERTKPRMT5FGFR1 | |
| SCHEMBL20290925 | 0.73 | LRRK2 (0.62) | LRRK2NEK2AURKAMERTKAXL | |
| SCHEMBL168477 | 0.73 | LRRK2 (0.47) | LRRK2CFDNEK2AURKAMERTK | |
| SCHEMBL169086 | 0.73 | LRRK2 (0.47) | LRRK2MERTKFGFR1FGFR3 | |
| SCHEMBL22837774 | 0.73 | LRRK2 (0.61) | LRRK2NEK2AURKAMERTKAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012028629-A1 | 2 - (BENZYLOXY) BENZAMIDES AS LRRK2 KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2012-03-08 | — | — | WO | disclosed |