⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7696998 | 0.83 | CYP4F2 (0.33) | — | |
| SCHEMBL3221343 | 0.79 | — | — | |
| SCHEMBL3495087 | 0.78 | — | — | |
| SCHEMBL13650261 | 0.77 | — | — | |
| SCHEMBL22616854 | 0.76 | — | — | |
| SCHEMBL37771 | 0.73 | — | — | |
| SCHEMBL8960812 | 0.69 | — | — | |
| SCHEMBL22750531 | 0.69 | — | — | |
| SCHEMBL1142967 | 0.69 | — | — | |
| SCHEMBL8960551 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230093861-A1 | RAPAMYCIN ANALOGS AS MTOR INHIBITORS | Revolution Medicines, Inc. | 2023-03-30 | — | — | US | disclosed |
| US-20210094975-A1 | RAPAMYCIN ANALOGS AS MTOR INHIBITORS | Revolution Medicines, Inc. | 2021-04-01 | — | — | US | disclosed |
| EP-3619216-A1 | RAPAMYCIN ANALOGS AS MTOR INHIBITORS | Revolution Medicines, Inc. (US) | 2020-03-11 | — | — | EP | disclosed |
| WO-2018204416-A1 | RAPAMYCIN ANALOGS AS MTOR INHIBITORS | Revolution Medicines, Inc. (US) | 2018-11-08 | — | — | WO | disclosed |
| EP-2459560-B1 | RING-ANNULATED DIHYDROPYRROLO[2,L-A]ISOQUINOLINES | MERCK SHARP & DOHME (NL) | 2015-08-19 | — | — | EP | disclosed |
| EP-2459560-B1 | RING-ANNULATED DIHYDROPYRROLO[2,L-A]ISOQUINOLINES | MERCK SHARP & DOHME (NL) | 2015-08-19 | — | — | EP | disclosed |
| US-8431564-B2 | Ring-annulated dihydropyrrolo[2,1-α]isoquinolines | MERCK SHARP & DOHME B.V. (NL) | 2013-04-30 | — | — | US | disclosed |
| US-8431564-B2 | Ring-annulated dihydropyrrolo[2,1-α]isoquinolines | MERCK SHARP & DOHME B.V. (NL) | 2013-04-30 | — | — | US | disclosed |
| US-8431564-B2 | Ring-annulated dihydropyrrolo[2,1-α]isoquinolines | MERCK SHARP & DOHME B.V. (NL) | 2013-04-30 | — | — | US | disclosed |
| US-8247595-B2 | Organic sulfur compound and its use for controlling harmful arthropod | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2012-08-21 | — | — | US | disclosed |
| EP-2459560-A1 | RING-ANNULATED DIHYDROPYRROLO[2,L-A]ISOQUINOLINES | MSD Oss B.V. (NL) | 2012-06-06 | — | — | EP | disclosed |
| US-20110028450-A1 | Ring-annulated dihydropyrrolo[2,1-alpha]isoquinolines | N.V. ORGANON (NL) | 2011-02-03 | — | — | US | disclosed |
| US-20110028450-A1 | Ring-annulated dihydropyrrolo[2,1-alpha]isoquinolines | N.V. ORGANON (NL) | 2011-02-03 | — | — | US | disclosed |
| US-20110028450-A1 | Ring-annulated dihydropyrrolo[2,1-alpha]isoquinolines | N.V. ORGANON (NL) | 2011-02-03 | — | — | US | disclosed |
| WO-2011012600-A1 | RING-ANNULATED DIHYDROPYRROLO[2,L-A]ISOQUINOLINES | N.V. ORGANON (NL) | 2011-02-03 | — | — | WO | disclosed |
| EP-2152668-B1 | ORGANIC SULFUR COMPOUND AND ITS USE FOR CONTROLLING HARMFUL ARTHROPODS | SUMITOMO CHEMICAL CO (JP) | 2011-01-12 | — | — | EP | disclosed |
| US-20100160434-A1 | ORGANIC SULFUR COMPOUND AND ITS USE FOR CONTROLLING HARMFUL ARTHROPOD | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2010-06-24 | — | — | US | disclosed |
| EP-2152668-A1 | ORGANIC SULFUR COMPOUND AND ITS USE FOR CONTROLLING HARMFUL ARTHROPOD | Sumitomo Chemical Company, Limited (JP) | 2010-02-17 | — | — | EP | disclosed |
| WO-2008143338-A1 | ORGANIC SULFUR COMPOUND AND ITS USE FOR CONTROLLING HARMFUL ARTHROPOD | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2008-11-27 | — | — | WO | disclosed |