Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 4/20 | 0.44 |
| ▸ | MIF | P14174 | 5/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.41 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10195022 | 0.81 | MAPK8 (0.48) | ITKMIFMAPK8MAPK3MAPK1 | |
| SCHEMBL10195545 | 0.81 | MAPT (0.47) | MIFMAPK8MAPK1MAPTMEN1 | |
| SCHEMBL10194751 | 0.80 | ITK (0.52) | ITKMIFMAPK8MAP2K4 | |
| SCHEMBL9953128 | 0.80 | MAPK1 (0.53) | ITKMIFMAPK8MAPK3MAPK1 | |
| SCHEMBL10194952 | 0.79 | HPGD (0.52) | MAPTMEN1KMT2A | |
| SCHEMBL10195548 | 0.79 | ITK (0.47) | ITKMIFMAPK8MAPK3MAPK1 | |
| SCHEMBL10195023 | 0.78 | KDM4E (0.54) | ITKMIFMAPK8MAPK1MAPK10 | |
| SCHEMBL10195025 | 0.78 | FLT3 (0.51) | ITKMIFMAPK8MAPK1MAP2K4 | |
| SCHEMBL9952538 | 0.78 | MAPK8 (0.45) | ITKMIFMAPK8MAPK3MAPK1 | |
| SCHEMBL10194946 | 0.77 | PARP1 (0.48) | MAPK8MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012084704-A1 | INDAZOLYL TRIAZOLE DERIVATIVES AS IRAK INHIBITORS | MERCK SERONO S.A. (CH) | 2012-06-28 | — | — | WO | disclosed |