Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.46 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.46 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.46 |
| ▸ | STAT3 | P40763 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.44 |
| ▸ | DDR2 | Q16832 | 3/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | MLYCD | O95822 | 1/20 | 0.42 |
| ▸ | P2RY14 | Q15391 | 2/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10194754 | 0.93 | JAK2 (0.47) | MAPK1MAP2K4MAPK6STAT3EPHX2 | |
| SCHEMBL10194762 | 0.89 | ABL1 (0.45) | MAPK1MAP2K4MAPK6EPHX2JAK2 | |
| SCHEMBL10196821 | 0.88 | JAK2 (0.46) | FGFR1JAK2MAPK10HPGDSMN1; SMN2 | |
| SCHEMBL9952517 | 0.87 | JAK2 (0.45) | JAK2MAPK10HPGDSMN1; SMN2FLT3 | |
| SCHEMBL10194705 | 0.87 | JAK2 (0.45) | JAK2MAPK10HPGDSMN1; SMN2FLT3 | |
| SCHEMBL10194710 | 0.87 | PHGDH (0.46) | MAP2K4JAK2MAPK10HPGDSMN1; SMN2 | |
| SCHEMBL10194923 | 0.86 | JAK2 (0.44) | JAK2MAPK10HPGDSMN1; SMN2FLT3 | |
| SCHEMBL10194768 | 0.85 | FLT3 (0.55) | MAP2K4MAPK6MAPKAPK5FGFR1DDR2 | |
| SCHEMBL10194789 | 0.85 | MAPK10 (0.47) | STAT3JAK2MAPK10HPGDSMN1; SMN2 | |
| SCHEMBL10194818 | 0.84 | JAK2 (0.43) | JAK2MAPK10HPGDSMN1; SMN2FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655357-B1 | INDAZOLYL TRIAZOLE DERIVATIVES AS IRAK INHIBITORS | MERCK SERONO SA (CH) | 2016-06-22 | — | — | EP | disclosed |
| US-9073892-B2 | Indazolyl triazol derivatives | MERCK SERONO S.A. (CH) | 2015-07-07 | — | — | US | disclosed |
| US-9073892-B2 | Indazolyl triazol derivatives | MERCK SERONO S.A. (CH) | 2015-07-07 | — | — | US | disclosed |
| US-20130274241-A1 | INDAZOLYL TRIAZOL DERIVATIVES | MERCK SERONO S.A. - INTELLECTUAL PROPERTY (CH) | 2013-10-17 | — | — | US | disclosed |
| US-20130274241-A1 | INDAZOLYL TRIAZOL DERIVATIVES | MERCK SERONO S.A. - INTELLECTUAL PROPERTY (CH) | 2013-10-17 | — | — | US | disclosed |
| WO-2012084704-A1 | INDAZOLYL TRIAZOLE DERIVATIVES AS IRAK INHIBITORS | MERCK SERONO S.A. (CH) | 2012-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130274241-A1 | INDAZOLYL TRIAZOL DERIVATIVES | NFATC1, IL5, CD4 | MAPK1 1717/4885MAP2K4 3270/4885MAPK6 1588/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.