SCHEMBL10195668

SCHEMBL10195668

CCCC(=O)OC1=C(c2cc(Oc3ccc(C#N)cc3F)ccc2CC)C(=O)C(C)(C)OC1(C)C

nearest known ligand 0.41

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
TBXA2R P21731 2/20 0.32
FFAR1 O14842 1/20 0.31
FFAR4 Q5NUL3 1/20 0.31
EGLN2 Q96KS0 2/20 0.30
EGLN1 Q9GZT9 2/20 0.30
GPR119 Q8TDV5 1/20 0.30
MAPK14 Q16539 1/20 0.30
USP30 Q70CQ3 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10195667 0.94 TBXA2R (0.31) TBXA2RFFAR1FFAR4GPR119USP30
SCHEMBL416035 0.91 TBXA2R (0.32) TBXA2RFFAR1FFAR4EGLN2EGLN1
SCHEMBL10195672 0.90 KDM4E (0.32) TBXA2R
SCHEMBL10254129 0.89 TBXA2R (0.33) TBXA2REGLN2EGLN1GPR119
SCHEMBL10195671 0.89 FFAR1 (0.32) TBXA2RFFAR1FFAR4GPR119USP30
SCHEMBL16351693 0.88 KMT2A (0.34) MAPK14
SCHEMBL10195099 0.85 HTR2A (0.33) TBXA2RFFAR1FFAR4EGLN2EGLN1
SCHEMBL16351686 0.81 PPARG (0.33) MAPK14
SCHEMBL16351673 0.79 PPARG (0.33) MAPK14
SCHEMBL16351668 0.78 KMT2A (0.37) MAPK14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2387569-B1 HERBCIDES SYNGENTA LTD (GB) 2016-06-15 EP disclosed
US-20140378305-A1 NOVEL HERBICIDES SYNGENTA LIMITED (GB) 2014-12-25 US disclosed
US-20140378305-A1 NOVEL HERBICIDES SYNGENTA LIMITED (GB) 2014-12-25 US disclosed
US-8865623-B2 Herbicidally active cyclic diones and derivatives thereof, processes for their preparation, compositions, and method of controlling weeds SYNGENTA LIMITED (GB) 2014-10-21 US disclosed
US-8865623-B2 Herbicidally active cyclic diones and derivatives thereof, processes for their preparation, compositions, and method of controlling weeds SYNGENTA LIMITED (GB) 2014-10-21 US disclosed
US-20120021907-A1 NOVEL HERBICIDES SYNGENTA CROP PROTECTION LLC (US) 2012-01-26 US disclosed
US-20120021907-A1 NOVEL HERBICIDES SYNGENTA CROP PROTECTION LLC (US) 2012-01-26 US disclosed
WO-2010081755-A1 NOVEL HERBICIDES SYNGENTA LIMITED (GB) 2010-07-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140378305-A1 NOVEL HERBICIDES DDT, CYP4X1, CYP1B1 TBXA2R 4116/4885FFAR1 1022/4885FFAR4 1065/4885
US-20120021907-A1 NOVEL HERBICIDES DDT, CYP4X1, CYP1B1 TBXA2R 4091/4885FFAR1 752/4885FFAR4 1124/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.