Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 2/20 | 0.37 |
| ▸ | FLT1 | P17948 | 2/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.36 |
| ▸ | MIF | P14174 | 1/20 | 0.35 |
| ▸ | MAP3K5 | Q99683 | 3/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.33 |
| ▸ | CDC7 | O00311 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17850431 | 1.00 | FGFR1 (0.37) | FGFR1FLT1ABL1GRM4SIGMAR1 | |
| SCHEMBL15312569 | 1.00 | FGFR1 (0.37) | FGFR1FLT1ABL1GRM4SIGMAR1 | |
| SCHEMBL15312570 | 1.00 | FGFR1 (0.37) | FGFR1FLT1ABL1GRM4SIGMAR1 | |
| SCHEMBL15312601 | 1.00 | FGFR1 (0.37) | FGFR1FLT1ABL1GRM4SIGMAR1 | |
| SCHEMBL10194803 | 0.90 | GRM4 (0.36) | FGFR1FLT1ABL1GRM4SIGMAR1 | |
| SCHEMBL10194867 | 0.87 | GRM4 (0.38) | FGFR1FLT1ABL1GRM4SIGMAR1 | |
| SCHEMBL10194801 | 0.87 | GRM4 (0.39) | FGFR1FLT1ABL1GRM4SIGMAR1 | |
| SCHEMBL10196871 | 0.87 | GRM4 (0.39) | FGFR1FLT1ABL1GRM4SIGMAR1 | |
| SCHEMBL15317781 | 0.83 | GRM4 (0.40) | FGFR1FLT1ABL1GRM4SIGMAR1 | |
| SCHEMBL10194770 | 0.83 | GRM4 (0.40) | FGFR1FLT1ABL1GRM4SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655357-B1 | INDAZOLYL TRIAZOLE DERIVATIVES AS IRAK INHIBITORS | MERCK SERONO SA (CH) | 2016-06-22 | — | — | EP | disclosed |
| WO-2012084704-A1 | INDAZOLYL TRIAZOLE DERIVATIVES AS IRAK INHIBITORS | MERCK SERONO S.A. (CH) | 2012-06-28 | — | — | WO | disclosed |