⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14012126 | 0.74 | KDM1A (0.33) | — | |
| SCHEMBL20143841 | 0.71 | — | — | |
| SCHEMBL7500475 | 0.71 | — | — | |
| SCHEMBL22571174 | 0.71 | CHEK1 (0.34) | — | |
| SCHEMBL12511064 | 0.70 | KDM1A (0.33) | — | |
| SCHEMBL19805350 | 0.68 | KDM6B (0.42) | — | |
| SCHEMBL12190242 | 0.68 | KDM1A (0.33) | — | |
| SCHEMBL20341004 | 0.68 | TSHR (0.41) | — | |
| SCHEMBL20622182 | 0.67 | GLA (0.36) | — | |
| SCHEMBL21389773 | 0.67 | KDM1A (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10787668-B2 | Fibrotic treatment | MONASH UNIVERSITY (AU) | 2020-09-29 | — | — | US | disclosed |
| US-20190249179-A1 | FIBROTIC TREATMENT | MONASH UNIVERSITY (AU) | 2019-08-15 | — | — | US | disclosed |
| US-9499485-B2 | Compounds that are S1P modulating agents and/or ATX modulating agents | BIOGEN MA INC. (US) | 2016-11-22 | — | — | US | disclosed |
| US-20150183741-A1 | COMPOUNDS THAT ARE S1P MODULATING AGENTS AND/OR ATX MODULATING AGENTS | BIOGEN MA INC. | 2015-07-02 | — | — | US | disclosed |
| US-8637507-B2 | Bicyclic compounds as inhibitors of diacylglycerol acyltransferase | MERCK SHARP & DOHME CORP. (US) | 2014-01-28 | — | — | US | disclosed |
| US-20120022057-A1 | BICYCLIC COMPOUNDS AS INHIBITORS OF DIACYGLYCEROL ACYLTRANSFERASE | SCHERING CORPORATION (US) | 2012-01-26 | — | — | US | disclosed |
| US-20120022057-A1 | BICYCLIC COMPOUNDS AS INHIBITORS OF DIACYGLYCEROL ACYLTRANSFERASE | SCHERING CORPORATION (US) | 2012-01-26 | — | — | US | disclosed |
| US-20110319403-A1 | BICYCLIC COMPOUNDS AS INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE | SCHERING CORPORATION (US) | 2011-12-29 | — | — | US | disclosed |
| US-20110224137-A1 | INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE | MERCK SHARP & DOHME CORP. | 2011-09-15 | — | — | US | disclosed |
| US-20110224136-A1 | INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE | MERCK SHARP & DOHME CORP | 2011-09-15 | — | — | US | disclosed |