Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 5/20 | 0.67 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.42 |
| ▸ | HTR3A | P46098 | 1/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.34 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.34 |
| ▸ | OGA | O60502 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1018526 | 0.85 | CHRNA7 (0.46) | CHRNA7 | |
| SCHEMBL1018315 | 0.82 | CHRNA7 (0.44) | CHRNA7 | |
| Abt-107 SCHEMBL373047 | 0.80 | CHRNA7 (1.00) | CHRNA7CHRNB2CHRNA4HTR3ACHRNB4 | |
| Abt-107 SCHEMBL527745 | 0.80 | CHRNA7 (1.00) | CHRNA7CHRNB2CHRNA4HTR3ACHRNB4 | |
| Abt-107 SCHEMBL1542259 | 0.80 | CHRNA7 (1.00) | CHRNA7CHRNB2CHRNA4HTR3ACHRNB4 | |
| Abt-107 SCHEMBL31393053 | 0.80 | CHRNA7 (1.00) | CHRNA7CHRNB2CHRNA4HTR3ACHRNB4 | |
| Abt-107 SCHEMBL29364159 | 0.80 | CHRNA7 (1.00) | CHRNA7CHRNB2CHRNA4HTR3ACHRNB4 | |
| SCHEMBL1019786 | 0.80 | CHRNA7 (0.44) | CHRNA7CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL3080565 | 0.80 | CHRNA7 (0.44) | CHRNA7 | |
| SCHEMBL1018510 | 0.80 | LSS (0.48) | CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1802616-B1 | NOVEL AZABICYCLIC ARYL DERIVATIVES AND THEIR MEDICAL USE | NEUROSEARCH AS (DK) | 2011-01-12 | — | — | EP | claimed |
| US-7652010-B2 | Azabicyclic aryl derivatives and their medical use | NEUROSEARCH A/S (DK) | 2010-01-26 | — | — | US | claimed |
| US-20070299082-A1 | Novel Azabicyclic Aryl Derivatives and Their Medical Use | ANIONA APS (DK) | 2007-12-27 | — | — | US | claimed |
| EP-1802616-B1 | NOVEL AZABICYCLIC ARYL DERIVATIVES AND THEIR MEDICAL USE | NEUROSEARCH AS (DK) | 2011-01-12 | — | — | EP | disclosed |
| US-7652010-B2 | Azabicyclic aryl derivatives and their medical use | NEUROSEARCH A/S (DK) | 2010-01-26 | — | — | US | disclosed |
| US-20070299082-A1 | Novel Azabicyclic Aryl Derivatives and Their Medical Use | ANIONA APS (DK) | 2007-12-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070299082-A1 | Novel Azabicyclic Aryl Derivatives and Their Medical Use | CHRNA6, CHRNA10, CHRNA5 | CHRNA7 6/4885CHRNB2 8/4885CHRNA4 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.