Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 9/20 | 0.50 |
| ▸ | CYP11B2 | P19099 | 9/20 | 0.50 |
| ▸ | NOTUM | Q6P988 | 7/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | EIF2AK3 | Q9NZJ5 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL868010 | 0.81 | CYP11B1 (0.53) | CYP11B1CYP11B2NOTUM | |
| SCHEMBL10198746 | 0.79 | CYP11B1 (0.43) | CYP11B1CYP11B2NOTUMKDM4EALDH1A1 | |
| SCHEMBL868870 | 0.74 | EIF2AK3 (0.67) | CYP11B1CYP11B2NOTUMEIF2AK3 | |
| SCHEMBL27975489 | 0.74 | EIF2AK3 (0.67) | CYP11B1CYP11B2NOTUMEIF2AK3 | |
| SCHEMBL14576479 | 0.73 | CYP11B1 (0.51) | CYP11B1CYP11B2NOTUMEIF2AK3 | |
| Hydrochloric Acid SCHEMBL6572261 | 0.72 | CYP11B1 (0.56) | CYP11B1CYP11B2NOTUMKDM4EALDH1A1 | |
| SCHEMBL615232 | 0.70 | NOTUM (0.69) | CYP11B1CYP11B2NOTUMKDM4EALDH1A1 | |
| SCHEMBL20760524 | 0.69 | NOTUM (0.62) | CYP11B1CYP11B2NOTUM | |
| SCHEMBL8239512 | 0.69 | CYP11B1 (0.82) | CYP11B1CYP11B2NOTUM | |
| SCHEMBL868699 | 0.68 | CYP11B1 (0.48) | CYP11B1CYP11B2NOTUMNPC1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130018038-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2013-01-17 | — | — | US | disclosed |
| US-20120077828-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2012-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130018038-A1 | CHEMICAL COMPOUNDS | BRCA1, IRS1, IGF1R | CYP11B1 341/4885CYP11B2 1031/4885NOTUM 2790/4885 |
| US-20120077828-A1 | CHEMICAL COMPOUNDS | BRCA1, IRS1, IGF1R | CYP11B1 341/4885CYP11B2 1031/4885NOTUM 2790/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.