Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 19/20 | 0.62 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14330691 | 1.00 | ALK (0.62) | ALKEGFR | |
| SCHEMBL30412123 | 0.90 | ALK (0.50) | ALKEGFR | |
| SCHEMBL30412698 | 0.90 | ALK (0.50) | ALKEGFR | |
| SCHEMBL30411599 | 0.89 | ALK (0.49) | ALKEGFR | |
| SCHEMBL30411639 | 0.89 | ALK (0.49) | ALKEGFR | |
| SCHEMBL26165404 | 0.89 | ALK (0.49) | ALKEGFR | |
| SCHEMBL14330686 | 0.88 | ALK (0.78) | ALKEGFR | |
| SCHEMBL16752951 | 0.84 | ALK (0.58) | ALK | |
| SCHEMBL10205822 | 0.83 | ALK (0.54) | ALKEGFR | |
| SCHEMBL30412078 | 0.82 | MAP4K4 (0.46) | ALKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655358-B1 | OXINDOLOPYRIMIDINE AS IGF1R RECEPTOR INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2014-11-19 | — | — | EP | disclosed |
| WO-2012085126-A1 | OXINDOLOPYRIMIDINE AS IGF1R RECEPTOR INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-28 | — | — | WO | disclosed |