Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 20/20 | 0.84 |
| ▸ | LCK | P06239 | 4/20 | 0.73 |
| ▸ | JAK2 | O60674 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10205966 | 0.97 | JAK3 (0.82) | JAK3LCKJAK2 | |
| SCHEMBL10207307 | 0.92 | JAK3 (1.00) | JAK3LCK | |
| SCHEMBL24961932 | 0.90 | JAK3 (0.94) | JAK3LCK | |
| SCHEMBL12911502 | 0.89 | JAK3 (0.85) | JAK3LCKJAK2 | |
| SCHEMBL12547543 | 0.89 | JAK3 (1.00) | JAK3LCKJAK2 | |
| SCHEMBL10206442 | 0.87 | JAK3 (1.00) | JAK3LCKJAK2 | |
| SCHEMBL12547211 | 0.87 | JAK3 (1.00) | JAK3LCKJAK2 | |
| SCHEMBL10207314 | 0.86 | JAK3 (0.85) | JAK3LCKJAK2 | |
| SCHEMBL10206468 | 0.86 | JAK3 (0.80) | JAK3LCK | |
| SCHEMBL12547077 | 0.86 | JAK3 (1.00) | JAK3LCKJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2460806-A1 | NITROGEN-CONTAINING SPIRO-RING COMPOUND AND MEDICINAL USE OF SAME | Japan Tobacco, Inc. (JP) | 2012-06-06 | — | — | EP | disclosed |