Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 5/20 | 0.57 |
| ▸ | EGFR | P00533 | 10/20 | 0.52 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.48 |
| ▸ | FLT4 | P35916 | 4/20 | 0.48 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.46 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.46 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10206591 | 0.94 | ALK (0.57) | ALKEGFRPTK2FLT4ERBB2 | |
| SCHEMBL14331661 | 0.89 | ALK (0.58) | ALKEGFRPTK2FLT4ERBB2 | |
| SCHEMBL10205083 | 0.89 | ALK (0.51) | ALKEGFRPTK2FLT4ERBB2 | |
| SCHEMBL10206590 | 0.88 | ALK (0.50) | ALKEGFRPTK2FLT4ERBB2 | |
| SCHEMBL10205532 | 0.88 | ALK (0.48) | ALKEGFRPTK2FLT4ERBB2 | |
| SCHEMBL10206586 | 0.87 | ALK (0.48) | ALKEGFRPTK2FLT4ERBB2 | |
| SCHEMBL10205049 | 0.84 | ALK (0.66) | ALKEGFR | |
| SCHEMBL10205849 | 0.83 | PTK2 (0.46) | PTK2FLT4 | |
| SCHEMBL10205538 | 0.82 | ALK (0.43) | ALKEGFRPTK2ERBB2ERBB3 | |
| SCHEMBL10205893 | 0.82 | ALK (0.53) | ALKEGFRPTK2FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085126-A1 | OXINDOLOPYRIMIDINE AS IGF1R RECEPTOR INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-28 | — | — | WO | disclosed |