Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 6/20 | 0.36 |
| ▸ | JAK3 | P52333 | 7/20 | 0.36 |
| ▸ | JAK1 | P23458 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | EGFR | P00533 | 2/20 | 0.34 |
| ▸ | TTK | P33981 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | TXK | P42681 | 1/20 | 0.34 |
| ▸ | BLK | P51451 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | ITK | Q08881 | 1/20 | 0.34 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.32 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10207051 | 0.95 | NTRK1 (0.37) | NTRK1JAK3JAK1JAK2EGFR | |
| SCHEMBL10206623 | 0.93 | JAK3 (0.37) | JAK3JAK1JAK2EGFRTTK | |
| SCHEMBL10206651 | 0.92 | PTK2 (0.39) | NTRK1JAK3JAK2LRRK2 | |
| SCHEMBL10207052 | 0.90 | JAK3 (0.35) | NTRK1JAK3JAK1JAK2EGFR | |
| SCHEMBL10206630 | 0.90 | JAK3 (0.37) | NTRK1JAK3JAK1JAK2EGFR | |
| SCHEMBL10206187 | 0.88 | EGFR (0.45) | JAK3JAK1JAK2EGFRTTK | |
| SCHEMBL10206653 | 0.87 | PTK2 (0.39) | NTRK1JAK3JAK2LRRK2 | |
| SCHEMBL10205874 | 0.84 | PTK2 (0.39) | NTRK1JAK3JAK2EGFRLRRK2 | |
| SCHEMBL10205180 | 0.84 | EGFR (0.41) | JAK3JAK1JAK2EGFRTTK | |
| SCHEMBL10206638 | 0.83 | ALK (0.42) | JAK3FLT3ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655358-B1 | OXINDOLOPYRIMIDINE AS IGF1R RECEPTOR INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2014-11-19 | — | — | EP | disclosed |
| US-8546443-B2 | Benzylic oxindole pyrimidines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-10-01 | — | — | US | disclosed |
| WO-2012085126-A1 | OXINDOLOPYRIMIDINE AS IGF1R RECEPTOR INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-28 | — | — | WO | disclosed |