Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 2/20 | 0.58 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.47 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | MRGPRX2 | Q96LB1 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.39 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1912051 | 1.00 | MAP4K4 (0.58) | MAP4K4HRH3HRH4PDE10AMAPK8 | |
| SCHEMBL1912119 | 0.91 | MAP4K4 (0.48) | MAP4K4HRH3HRH4PDE10AHRH1 | |
| SCHEMBL14938741 | 0.81 | MAP4K4 (0.40) | MAP4K4HRH3HRH4PDE10A | |
| SCHEMBL2069373 | 0.79 | SMPD3 (0.46) | PDE10A | |
| SCHEMBL2069375 | 0.79 | SMPD3 (0.46) | PDE10A | |
| SCHEMBL2068649 | 0.79 | SMPD3 (0.46) | PDE10A | |
| SCHEMBL2142219 | 0.78 | MAP4K4 (0.52) | MAP4K4HRH3HRH4PDE10AHRH1 | |
| SCHEMBL25188971 | 0.77 | MEN1 (0.47) | HRH3KCNH2 | |
| SCHEMBL14981293 | 0.77 | HRH4 (0.59) | HRH3HRH4 | |
| SCHEMBL13279806 | 0.77 | MAP4K4 (0.54) | MAP4K4HRH3HRH4PDE10AMAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2287156-B1 | 2,4-Di(phenylamino)-pyrimidines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders | NOVARTIS AG (CH) | 2013-05-29 | — | — | EP | disclosed |
| EP-1660458-B1 | 2, 4-PYRIMIDINEDIAMINES USEFUL IN THE TREATMENT OF NEOPLASTIC DISEASES, INFLAMMATORY AND IMMUNE SYSTEM DISORDERS | NOVARTIS AG (CH) | 2012-01-25 | — | — | EP | disclosed |