Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | DHFR | P00374 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10209681 | 1.00 | MEN1 (0.34) | MEN1ALDH1A1MAPTKMT2AHSD17B10 | |
| SCHEMBL988728 | 0.94 | MEN1 (0.35) | MEN1ALDH1A1MAPTKMT2AHSD17B10 | |
| SCHEMBL988729 | 0.94 | MEN1 (0.35) | MEN1ALDH1A1MAPTKMT2AHSD17B10 | |
| SCHEMBL989396 | 0.93 | TYMS (0.35) | MEN1ALDH1A1MAPTKMT2AHSD17B10 | |
| SCHEMBL989399 | 0.93 | TYMS (0.35) | MEN1ALDH1A1MAPTKMT2AHSD17B10 | |
| SCHEMBL990715 | 0.92 | MEN1 (0.34) | MEN1ALDH1A1MAPTKMT2AHSD17B10 | |
| SCHEMBL3219438 | 0.92 | MEN1 (0.34) | MEN1ALDH1A1MAPTKMT2AHSD17B10 | |
| SCHEMBL990714 | 0.92 | MEN1 (0.34) | MEN1ALDH1A1MAPTKMT2AHSD17B10 | |
| SCHEMBL15180103 | 0.91 | MEN1 (0.35) | MEN1ALDH1A1MAPTKMT2AHSD17B10 | |
| SCHEMBL13255693 | 0.89 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8809526-B2 | Synthesis of cyclopentaquinazolines | ONYX PHARMACEUTICALS, INC. (US) | 2014-08-19 | — | — | US | disclosed |
| US-8809526-B2 | Synthesis of cyclopentaquinazolines | ONYX PHARMACEUTICALS, INC. (US) | 2014-08-19 | — | — | US | disclosed |
| WO-2012011939-A2 | SYNTHESIS OF CYCLOPENTAQUINAZOLINES | ONYX PHARMACEUTICALS, INC. (US) | 2012-01-26 | — | — | WO | disclosed |