Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 11/20 | 0.58 |
| ▸ | DDB1 | Q16531 | 5/20 | 0.58 |
| ▸ | TNF | P01375 | 1/20 | 0.58 |
| ▸ | IL1B | P01584 | 1/20 | 0.58 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.58 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | CCNK | O75909 | 1/20 | 0.38 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18509456 | 0.91 | CRBN (0.55) | CRBNDDB1TNFIL1BIKZF3 | |
| SCHEMBL2603184 | 0.89 | CRBN (0.53) | CRBNDDB1TNFIL1BIKZF3 | |
| SCHEMBL282662 | 0.87 | CRBN (0.56) | CRBNDDB1TNFIL1BIKZF3 | |
| SCHEMBL26672061 | 0.86 | CRBN (0.61) | CRBNDDB1TNFIL1BIKZF3 | |
| SCHEMBL26320556 | 0.86 | CRBN (0.63) | CRBNDDB1TNFIL1BIKZF3 | |
| SCHEMBL282837 | 0.86 | CRBN (0.63) | CRBNDDB1TNFIL1BIKZF3 | |
| SCHEMBL31316579 | 0.86 | CRBN (0.63) | CRBNDDB1TNFIL1BIKZF3 | |
| SCHEMBL18900417 | 0.86 | CRBN (0.63) | CRBNDDB1TNFIL1BIKZF3 | |
| SCHEMBL282858 | 0.85 | CRBN (0.62) | CRBNDDB1TNFIL1BIKZF3 | |
| SCHEMBL26320519 | 0.85 | CRBN (0.62) | CRBNDDB1TNFIL1BIKZF3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3925609-A1 | METHODS OF TREATING MULTIPLE MYELOMA WITH IMMUNOMODULATORY COMPOUNDS IN COMBINATION WITH ANTIBODIES | Celgene Corporation (US) | 2021-12-22 | — | — | EP | disclosed |
| EP-2420498-B1 | 5-substituted quinazolinone derivatives as anti-cancer agents | CELGENE CORP (US) | 2017-05-31 | — | — | EP | disclosed |
| EP-2428513-B1 | 5-substituted quinazolinone derivatives as anti-cancer agents | CELGENE CORP (US) | 2017-05-31 | — | — | EP | disclosed |
| WO-2017027672-A1 | METHODS FOR TREATING SOLID TUMORS AND THE USE OF BIOMARKERS AS A PREDICTOR OF CLINICAL SENSITIVITY TO IMMUNOMODULATORY THERAPIES | CELGENE CORPORATION (US) | 2017-02-16 | — | — | WO | disclosed |
| WO-2016196580-A1 | METHODS FOR DETERMINING DRUG EFFICACY FOR TREATMENT OF CANCER USING RATIOS OF CEREBLON ASSOCIATED PROTEINS | CELGENE CORPORATION (US) | 2016-12-08 | — | — | WO | disclosed |
| WO-2016060702-A1 | METHODS FOR TREATING SOLID TUMORS AND THE USE OF BIOMARKERS AS A PREDICTOR OF CLINICAL SENSITIVITY TO IMMUNOMODULATORY THERAPIES | CELGENE CORPORATON (US) | 2016-04-21 | — | — | WO | disclosed |
| EP-2420497-B1 | 5-substituted quinazolinone derivatives as anti-cancer agents | CELGENE CORP (US) | 2015-12-16 | — | — | EP | disclosed |
| WO-2013106686-A1 | BIOMARKERS FOR THE TREATMENT OF HEPATOCELLULAR CARCINOMA | CELGENE CORPORATION (US) | 2013-07-18 | — | — | WO | disclosed |
| EP-2428513-A1 | 5-substituted quinazolinone derivatives as anti-cancer agents | Celgene Corporation (US) | 2012-03-14 | — | — | EP | disclosed |
| EP-2420497-A1 | 5-substituted quinazolinone derivatives as anti-cancer agents | CELGENE CORPORATION (US) | 2012-02-22 | — | — | EP | disclosed |
| EP-2420498-A1 | 5-substituted quinazolinone derivatives as anti-cancer agents | Celgene Corporation (US) | 2012-02-22 | — | — | EP | disclosed |