Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 16/20 | 0.55 |
| ▸ | CCNA2 | P20248 | 18/20 | 0.54 |
| ▸ | CDK2 | P24941 | 18/20 | 0.54 |
| ▸ | CCNA1 | P78396 | 16/20 | 0.54 |
| ▸ | AURKA | O14965 | 10/20 | 0.53 |
| ▸ | PLK3 | Q9H4B4 | 9/20 | 0.53 |
| ▸ | PLK2 | Q9NYY3 | 9/20 | 0.53 |
| ▸ | TTK | P33981 | 4/20 | 0.53 |
| ▸ | CDK4 | P11802 | 3/20 | 0.53 |
| ▸ | CCND3 | P30281 | 3/20 | 0.53 |
| ▸ | CDK6 | Q00534 | 3/20 | 0.53 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.51 |
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
| ▸ | KIT | P10721 | 1/20 | 0.51 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.51 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.51 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.51 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.51 |
| ▸ | FLT4 | P35916 | 1/20 | 0.51 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11025830 | 0.86 | PLK1 (0.65) | PLK1CCNA2CDK2CCNA1AURKA | |
| SCHEMBL10218678 | 0.85 | CCNA2 (0.59) | PLK1CCNA2CDK2CCNA1AURKA | |
| Trifluoroacetic Acid SCHEMBL11023473 | 0.82 | PLK1 (0.63) | PLK1CCNA2CDK2CCNA1AURKA | |
| SCHEMBL9940866 | 0.80 | CCNA2 (0.61) | PLK1CCNA2CDK2CCNA1AURKA | |
| SCHEMBL9940913 | 0.80 | CCNA2 (0.65) | PLK1CCNA2CDK2CCNA1AURKA | |
| SCHEMBL9940668 | 0.80 | CCNA2 (0.65) | PLK1CCNA2CDK2CCNA1AURKA | |
| SCHEMBL9940794 | 0.79 | CCNA2 (0.69) | PLK1CCNA2CDK2CCNA1AURKA | |
| SCHEMBL9940400 | 0.78 | CCNA2 (0.64) | PLK1CCNA2CDK2CCNA1AURKA | |
| SCHEMBL9940837 | 0.78 | CCNA2 (0.60) | PLK1CCNA2CDK2CCNA1AURKA | |
| SCHEMBL10220009 | 0.78 | PLK1 (0.65) | PLK1CCNA2CDK2CCNA1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012080990-A1 | SUBSTITUTED PYRAZOLO-QUINAZOLINE DERIVATIVES AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-06-21 | — | — | WO | disclosed |