Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | SCD | O00767 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5864882 | 0.99 | POLB (0.53) | POLBCYP2C9PDE7ASLC6A2SLC6A3 | |
| SCHEMBL1026448 | 0.99 | POLB (0.53) | POLBCYP2C9PDE7ASLC6A2SLC6A3 | |
| SCHEMBL1022365 | 0.99 | POLB (0.53) | POLBCYP2C9PDE7ASLC6A2SLC6A3 | |
| SCHEMBL1022364 | 0.99 | POLB (0.53) | POLBCYP2C9PDE7ASLC6A2SLC6A3 | |
| SCHEMBL1022366 | 0.99 | POLB (0.53) | POLBCYP2C9PDE7ASLC6A2SLC6A3 | |
| SCHEMBL1022368 | 0.96 | POLB (0.51) | POLBCYP2C9PDE7ASLC6A2SLC6A3 | |
| SCHEMBL4177641 | 0.84 | POLB (0.54) | POLBSLC6A2SLC6A3MAPTALDH1A1 | |
| SCHEMBL31203149 | 0.84 | CYP2C9 (0.49) | CYP2C9PDE7AHSD17B10MAPTALDH1A1 | |
| SCHEMBL27265100 | 0.83 | HSD17B10 (0.53) | CYP2C9PDE7AHSD17B10MAPTALDH1A1 | |
| SCHEMBL3979711 | 0.83 | SCD (0.51) | POLBCYP2C9PDE7AHSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1987006-B1 | NOVEL AMINOALCOHOL-SUBSTITUTED ARYLDIHYDROISOQUINOLINONES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | SANOFI AVENTIS (FR) | 2011-01-12 | — | — | EP | disclosed |