SCHEMBL10225337

SCHEMBL10225337

NS(=O)(=O)c1ccc(N[C@H](CCN2CCO[C@@H](CO)C2)CSc2ccccc2)c(S(=O)(=O)C(F)(F)F)c1

nearest known ligand 0.77

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
BCL2L1 Q07817 19/20 0.77
BCL2 P10415 17/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10225736 1.00 BCL2L1 (0.77) BCL2L1BCL2
SCHEMBL29424529 1.00 BCL2L1 (0.77) BCL2L1BCL2
SCHEMBL555005 0.89 BCL2L1 (0.72) BCL2L1BCL2
SCHEMBL554138 0.89 BCL2L1 (0.72) BCL2L1BCL2
SCHEMBL554139 0.89 BCL2L1 (0.72) BCL2L1BCL2
SCHEMBL554140 0.89 BCL2L1 (0.72) BCL2L1BCL2
SCHEMBL30777653 0.87 BCL2L1 (1.00) BCL2L1BCL2
SCHEMBL554095 0.87 BCL2L1 (1.00) BCL2L1BCL2
SCHEMBL554094 0.87 BCL2L1 (1.00) BCL2L1BCL2
SCHEMBL10226512 0.87 BCL2L1 (0.67) BCL2L1BCL2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114126616-A Nanoparticle formulations of BCL-2 inhibitors 里科瑞尔姆IP控股有限责任公司 2022-03-01 CN disclosed