Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 13/20 | 0.47 |
| ▸ | JAK1 | P23458 | 10/20 | 0.47 |
| ▸ | JAK2 | O60674 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10228213 | 0.82 | CHEK1 (0.44) | JAK3JAK1JAK2CHEK1KCNH2 | |
| SCHEMBL17545962 | 0.78 | JAK1 (0.46) | JAK3JAK1JAK2MEN1KMT2A | |
| SCHEMBL13774321 | 0.76 | JAK3 (0.59) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL2733906 | 0.75 | CHEK1 (0.52) | JAK3JAK1JAK2CHEK1KCNH2 | |
| SCHEMBL17545881 | 0.74 | JAK1 (0.47) | JAK3JAK1JAK2MAPTCHEK1 | |
| SCHEMBL18465519 | 0.74 | SMN1; SMN2 (0.47) | JAK3JAK1JAK2MEN1KMT2A | |
| SCHEMBL20183452 | 0.74 | JAK3 (0.76) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL14615713 | 0.74 | JAK3 (0.76) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL22510598 | 0.73 | JAK3 (0.54) | JAK3JAK1JAK2MEN1KMT2A | |
| SCHEMBL17545876 | 0.71 | CHEK1 (0.54) | JAK3JAK1JAK2CHEK1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012058645-A1 | HETEROCYCLIC TYROSINE KINASE INHIBITORS | BIOGEN IDEC MA INC. (US) | 2012-05-03 | — | — | WO | disclosed |