Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 2/20 | 0.76 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | PDE2A | O00408 | 1/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | PDE1A | P54750 | 1/20 | 0.47 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.47 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL795392 | 0.98 | PIK3CD (0.77) | PIK3CDPIK3R1ALDH1A1MAPK1PDE2A | |
| SCHEMBL15485490 | 0.96 | PIK3CD (0.79) | PIK3CDPIK3R1ALDH1A1MAPK1PDE2A | |
| SCHEMBL798698 | 0.93 | PIK3CD (0.75) | PIK3CDPIK3R1ALDH1A1MAPK1PDE2A | |
| SCHEMBL798699 | 0.93 | PIK3CD (0.75) | PIK3CDPIK3R1ALDH1A1MAPK1PDE2A | |
| SCHEMBL788137 | 0.91 | PIK3CD (0.72) | PIK3CDPIK3R1ALDH1A1MAPK1PDE2A | |
| SCHEMBL788143 | 0.90 | PIK3CD (0.81) | PIK3CDPIK3R1ALDH1A1MAPK1PDE2A | |
| SCHEMBL18175790 | 0.90 | PIK3CD (0.64) | PIK3CDPIK3R1ALDH1A1MAPK1PDE2A | |
| SCHEMBL787958 | 0.89 | PIK3CD (0.77) | PIK3CDPIK3R1ALDH1A1MAPK1PDE2A | |
| SCHEMBL787863 | 0.89 | PIK3CD (0.82) | PIK3CDPIK3R1ALDH1A1PDE2APDE4A | |
| SCHEMBL15485458 | 0.89 | PIK3CD (0.79) | PIK3CDPIK3R1ALDH1A1PDE2APDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616469-B1 | 9H-PURINE COMPOUNDS AS PI3K-DELTA INHIBITORS AND METHODS FOR THEIR MANUFACTURE | EXELIXIS INC (US) | 2016-10-26 | — | — | EP | disclosed |
| WO-2012037226-A1 | INHIBITORS OF PI3K-DELTA AND METHODS OF THEIR USE AND MANUFACTURE | EXELIXIS, INC. (US) | 2012-03-22 | — | — | WO | disclosed |