Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 7/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KLF10 | Q13118 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 3/20 | 0.33 |
| ▸ | SYK | P43405 | 3/20 | 0.33 |
| ▸ | GSK3A | P49840 | 3/20 | 0.33 |
| ▸ | SCARB1 | Q8WTV0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19047473 | 0.89 | MAPK14 (0.43) | MAPK14MAPTKLF10CYP2C19MEN1 | |
| SCHEMBL16106451 | 0.83 | MAPK14 (0.50) | MAPK14MAPTMEN1HTTKMT2A | |
| SCHEMBL13458465 | 0.83 | CYP2C19 (0.54) | MAPK14MAPTCYP2C19MEN1HTT | |
| SCHEMBL13458599 | 0.83 | MAPK14 (0.34) | MAPK14MAPTCYP2C19MEN1HTT | |
| SCHEMBL27935808 | 0.81 | MAPT (0.43) | MAPK14MAPTKLF10CYP2C19PDE4A | |
| SCHEMBL12929955 | 0.81 | MAPT (0.43) | MAPK14MAPTKLF10CYP2C19PDE4A | |
| SCHEMBL15086934 | 0.80 | MAPK14 (0.33) | MAPK14MAPTCYP2C19MEN1HTT | |
| SCHEMBL15086976 | 0.80 | MAPK14 (0.44) | MAPK14MEN1HTTKMT2ABCL2A1 | |
| SCHEMBL6407060 | 0.79 | MAPT (0.42) | MAPK14MAPTKLF10CYP2C19HTT | |
| SCHEMBL15086935 | 0.78 | MAPK14 (0.40) | MAPK14MEN1HTTKMT2ABCL2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2331506-B1 | NOVEL BENZAMIDES, PRODUCTION THEREOF, AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM INT (DE) | 2013-07-03 | — | — | EP | disclosed |
| EP-2323980-B1 | 7-(PIPERAZINE-1-YMETHYL)-1H-INDOLE-2-CARBOXYLIC ACID (PHENYL)-AMIDE DERIVATIVES AND ALLIED COMPOUNDS AS P38 MAP KINASE INHIBITORS FOR THE TREATMENT OF RESPIRATORY DISEASES | BOEHRINGER INGELHEIM INT (DE) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010026095-A1 | NOVEL BENZAMIDES, PRODUCTION THEREOF, AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-03-11 | — | — | WO | disclosed |