Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 8/20 | 0.41 |
| ▸ | RPTOR | Q8N122 | 3/20 | 0.41 |
| ▸ | MLST8 | Q9BVC4 | 3/20 | 0.41 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.37 |
| ▸ | AKT2 | P31751 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 9/20 | 0.37 |
| ▸ | KDR | P35968 | 8/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 6/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10234699 | 0.93 | MTOR (0.42) | MTORRPTORMLST8METCDK2 | |
| SCHEMBL10234681 | 0.91 | MTOR (0.40) | MTORRPTORMLST8CDK2CHEK1 | |
| SCHEMBL10239910 | 0.91 | MTOR (0.41) | MTORRPTORMLST8CDK2CHEK1 | |
| SCHEMBL10234831 | 0.90 | MTOR (0.42) | MTORRPTORMLST8METCDK2 | |
| SCHEMBL10235107 | 0.90 | MTOR (0.42) | MTORRPTORMLST8METCDK2 | |
| SCHEMBL7882636 | 0.90 | CHEK1 (0.44) | MTORRPTORMLST8TNK2MET | |
| SCHEMBL10239903 | 0.89 | MTOR (0.43) | MTORRPTORMLST8METCDK2 | |
| SCHEMBL10234682 | 0.89 | MTOR (0.40) | MTORRPTORMLST8CDK2CHEK1 | |
| SCHEMBL10234858 | 0.89 | MTOR (0.43) | MTORRPTORMLST8CDK2CHEK1 | |
| SCHEMBL10234695 | 0.88 | NPC1 (0.42) | MTORRPTORMLST8CDK2CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120114739-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | MERCK SHARP & DOHME LLC | 2012-05-10 | — | — | US | disclosed |
| US-20120114739-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | MERCK SHARP & DOHME LLC | 2012-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120114739-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | MTOR, RICTOR, RPTOR | MTOR 1/4885RPTOR 3/4885MLST8 15/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.