Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 20/20 | 0.57 |
| ▸ | MAP2K2 | P36507 | 3/20 | 0.51 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.51 |
| ▸ | EIF2AK1 | Q9BQI3 | 1/20 | 0.51 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.47 |
| ▸ | NQO2 | P16083 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1021655 | 0.89 | MAP2K1 (0.57) | MAP2K1MAP2K2MAP2K5EIF2AK1ABCB11 | |
| SCHEMBL392066 | 0.84 | MAP2K1 (0.67) | MAP2K1MAP2K2MAP2K5EIF2AK1ABCB11 | |
| SCHEMBL14631994 | 0.84 | MAP2K1 (0.54) | MAP2K1MAP2K2MAP2K5EIF2AK1ABCB11 | |
| SCHEMBL1021500 | 0.81 | MAP2K1 (0.53) | MAP2K1MAP2K2MAP2K5EIF2AK1ABCB11 | |
| SCHEMBL15463553 | 0.80 | MAP2K1 (0.74) | MAP2K1MAP2K2ABCB11NQO2 | |
| SCHEMBL391555 | 0.80 | MAP2K1 (0.66) | MAP2K1MAP2K2MAP2K5EIF2AK1ABCB11 | |
| SCHEMBL12954592 | 0.79 | MAP2K1 (0.65) | MAP2K1MAP2K2MAP2K5EIF2AK1ABCB11 | |
| SCHEMBL393158 | 0.79 | MAP2K1 (0.79) | MAP2K1MAP2K2MAP2K5EIF2AK1ABCB11 | |
| SCHEMBL388723 | 0.78 | MAP2K1 (0.64) | MAP2K1MAP2K2MAP2K5EIF2AK1ABCB11 | |
| SCHEMBL388763 | 0.78 | MAP2K1 (0.67) | MAP2K1MAP2K2MAP2K5EIF2AK1ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2251327-B1 | HETEROCYCLIC INHIBITORS OF MEK | ARRAY BIOPHARMA INC (US) | 2014-02-12 | — | — | EP | claimed |
| EP-1682138-B3 | HETEROCYCLIC INHIBITORS OF MEK | ARRAY BIOPHARMA INC (US) | 2013-01-09 | — | — | EP | claimed |
| EP-1682138-B1 | HETEROCYCLIC INHIBITORS OF MEK | ARRAY BIOPHARMA INC (US) | 2011-01-12 | — | — | EP | claimed |