Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RAD52 | P43351 | 1/20 | 0.31 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13242285 | 0.81 | KDM4E (0.36) | KDM4ECHRNA7ALDH1A1SMN1; SMN2GAA | |
| SCHEMBL14328689 | 0.81 | KDM4E (0.36) | KDM4ECHRNA7ALDH1A1SMN1; SMN2GAA | |
| SCHEMBL14328675 | 0.81 | KDM4E (0.36) | KDM4ECHRNA7ALDH1A1SMN1; SMN2GAA | |
| SCHEMBL14748126 | 0.79 | MC4R (0.36) | KDM4EALDH1A1 | |
| SCHEMBL14748115 | 0.78 | SMN1; SMN2 (0.33) | SMN1; SMN2 | |
| SCHEMBL20970560 | 0.77 | KDM4E (0.37) | KDM4ECHRNA7ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL12850091 | 0.76 | KDM4E (0.37) | KDM4ECHRNA7ALDH1A1SMN1; SMN2GAA | |
| SCHEMBL10284434 | 0.76 | SMN1; SMN2 (0.36) | SMN1; SMN2MAPTL3MBTL1 | |
| SCHEMBL19871771 | 0.76 | SMN1; SMN2 (0.36) | SMN1; SMN2MAPTL3MBTL1 | |
| SCHEMBL17482104 | 0.75 | DAO (0.38) | KDM4ECHRNA7ALDH1A1SMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2389372-B1 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | RIGEL PHARMACEUTICALS INC (US) | 2015-09-09 | — | — | EP | disclosed |
| EP-2565193-A1 | Compositions and methods for inhibition of the JAK pathway | Rigel Pharmaceuticals, Inc. (US) | 2013-03-06 | — | — | EP | disclosed |
| WO-2012015972-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | RIGEL PHARMACEUTICALS, INC. (US) | 2012-02-02 | — | — | WO | disclosed |
| WO-2010085684-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | RIGEL PHARMACEUTICALS, INC. (US) | 2010-07-29 | — | — | WO | disclosed |