Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 11/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 8/20 | 0.39 |
| ▸ | NRAS | P01111 | 2/20 | 0.34 |
| ▸ | CLK2 | P49760 | 1/20 | 0.33 |
| ▸ | CLK3 | P49761 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10239879 | 0.87 | FLT3 (0.60) | FLT3IRAK4NRASKDR | |
| SCHEMBL10239867 | 0.86 | FLT3 (0.47) | FLT3IRAK4NRASCLK2CLK3 | |
| SCHEMBL12553680 | 0.86 | FLT3 (0.42) | FLT3IRAK4NRASMAPK8 | |
| SCHEMBL10238528 | 0.85 | FLT3 (0.42) | FLT3IRAK4NRAS | |
| SCHEMBL10239098 | 0.85 | IRAK4 (0.56) | FLT3IRAK4MAPK8 | |
| SCHEMBL10239508 | 0.83 | FLT3 (0.58) | FLT3IRAK4NRASKDR | |
| SCHEMBL10238526 | 0.82 | IRAK4 (0.57) | FLT3IRAK4NRASKDR | |
| SCHEMBL13494284 | 0.80 | FLT3 (0.39) | FLT3IRAK4NRASPIM1PIM3 | |
| SCHEMBL10239492 | 0.80 | FLT3 (0.39) | FLT3IRAK4NRASFGFR3KDR | |
| SCHEMBL12553679 | 0.77 | FLT3 (0.59) | FLT3IRAK4NRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2328890-B1 | 6 SUBSTITUTED 2-HETEROCYCLYLAMINO PYRAZINE COMPOUNDS AS CHK-1 INHIBITORS | PFIZER (US) | 2012-01-25 | — | — | EP | disclosed |
| WO-2010016005-A1 | 6 SUBSTITUTED 2-HETEROCYCLYLAMINO PYRAZINE COMPOUNDS AS CHK-1 INHIBITORS | PFIZER INC. (US) | 2010-02-11 | — | — | WO | disclosed |