Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 7/20 | 0.37 |
| ▸ | CDK2 | P24941 | 7/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 6/20 | 0.37 |
| ▸ | CCNA1 | P78396 | 6/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10235164 | 0.93 | CHEK1 (0.37) | CCNA2CDK2CHEK1CCNA1ALDH1A1 | |
| SCHEMBL7886194 | 0.92 | ABCG2 (0.35) | CCNA2CDK2ALDH1A1PIK3CBMTOR | |
| SCHEMBL7874844 | 0.88 | CHEK1 (0.40) | CCNA2CDK2CHEK1CCNA1ALDH1A1 | |
| SCHEMBL7879290 | 0.86 | CCNA2 (0.39) | CCNA2CDK2CHEK1CCNA1MAP4K4 | |
| SCHEMBL7879298 | 0.85 | CHEK1 (0.40) | CCNA2CDK2CHEK1CCNA1ALDH1A1 | |
| SCHEMBL7885294 | 0.85 | MAP4K4 (0.43) | CCNA2CDK2CHEK1CCNA1MAP4K4 | |
| SCHEMBL7878930 | 0.84 | CCNA2 (0.38) | CCNA2CDK2CHEK1CCNA1ALDH1A1 | |
| SCHEMBL10239216 | 0.83 | CHEK1 (0.39) | CCNA2CDK2CHEK1CCNA1ALDH1A1 | |
| SCHEMBL589188 | 0.82 | CHEK1 (0.39) | CCNA2CDK2CHEK1CCNA1ALDH1A1 | |
| SCHEMBL7883203 | 0.81 | CHEK1 (0.39) | CCNA2CDK2CHEK1CCNA1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120114739-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | MERCK SHARP & DOHME LLC | 2012-05-10 | — | — | US | disclosed |
| US-20120114739-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | MERCK SHARP & DOHME LLC | 2012-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120114739-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | MTOR, RICTOR, RPTOR | CCNA2 2476/4885CDK2 165/4885CHEK1 461/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.