Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 6/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 5/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.38 |
| ▸ | CDK2 | P24941 | 5/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 5/20 | 0.38 |
| ▸ | RET | P07949 | 3/20 | 0.37 |
| ▸ | KIF5B | P33176 | 3/20 | 0.37 |
| ▸ | KDR | P35968 | 3/20 | 0.37 |
| ▸ | ETV6 | P41212 | 3/20 | 0.37 |
| ▸ | CCDC6 | Q16204 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | CASP3 | P42574 | 2/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.37 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10239757 | 1.00 | PIM1 (0.39) | PIM1PIM2CHEK1CCNA2CDK2 | |
| SCHEMBL7875031 | 0.89 | PIK3CA (0.41) | CHEK1CCNA2CDK2CCNA1MEN1 | |
| SCHEMBL7878718 | 0.89 | PIK3CA (0.41) | CHEK1CCNA2CDK2CCNA1MEN1 | |
| SCHEMBL6889175 | 0.86 | MTOR (0.44) | CHEK1CCNA2CDK2CCNA1KDR | |
| SCHEMBL10277202 | 0.86 | MTOR (0.44) | CHEK1CCNA2CDK2CCNA1KDR | |
| SCHEMBL10236906 | 0.84 | CHEK1 (0.42) | PIM1CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL10234435 | 0.83 | CHEK1 (0.38) | PIM1CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL7874679 | 0.82 | NEK2 (0.45) | KDRMEN1KMT2ANPC1ALDH1A1 | |
| SCHEMBL10234433 | 0.82 | KDR (0.37) | CHEK1CCNA2CDK2CCNA1RET | |
| SCHEMBL7881735 | 0.82 | CHEK1 (0.34) | CHEK1CCNA2CDK2CCNA1RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120114739-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | MERCK SHARP & DOHME LLC | 2012-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120114739-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | MTOR, RICTOR, RPTOR | PIM1 255/4885PIM2 400/4885CHEK1 461/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.