Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 9/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | KCNK3 | O14649 | 3/20 | 0.40 |
| ▸ | KCNK9 | Q9NPC2 | 3/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.40 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.40 |
| ▸ | JUN | P05412 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.39 |
| ▸ | IGF1R | P08069 | 2/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL376063 | 0.85 | EIF2AK4 (0.40) | FLT3USP30 | |
| SCHEMBL10239065 | 0.85 | MAPK8 (0.48) | IRAK4FLT3MAPK8MAPK9CDK2 | |
| SCHEMBL376257 | 0.84 | IRAK4 (0.45) | IRAK4FLT3MAPK8MAPK9CDK2 | |
| SCHEMBL376256 | 0.84 | IRAK4 (0.45) | IRAK4FLT3MAPK8MAPK9CDK2 | |
| SCHEMBL376678 | 0.84 | IRAK4 (0.45) | IRAK4FLT3MAPK8MAPK9CDK2 | |
| SCHEMBL24232003 | 0.82 | IRAK4 (0.50) | IRAK4FLT3MAPK8MAPK9CDK2 | |
| SCHEMBL376305 | 0.78 | IRAK4 (0.45) | IRAK4FLT3MAPK8MAPK9CDK2 | |
| SCHEMBL376467 | 0.76 | IRAK4 (0.58) | IRAK4FLT3MAPK8MAPK9MAPK10 | |
| SCHEMBL376466 | 0.76 | IRAK4 (0.58) | IRAK4FLT3MAPK8MAPK9MAPK10 | |
| SCHEMBL376148 | 0.76 | USP30 (0.44) | USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2328890-B1 | 6 SUBSTITUTED 2-HETEROCYCLYLAMINO PYRAZINE COMPOUNDS AS CHK-1 INHIBITORS | PFIZER (US) | 2012-01-25 | — | — | EP | disclosed |
| WO-2010016005-A1 | 6 SUBSTITUTED 2-HETEROCYCLYLAMINO PYRAZINE COMPOUNDS AS CHK-1 INHIBITORS | PFIZER INC. (US) | 2010-02-11 | — | — | WO | disclosed |