Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 2/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CACNA1H | O95180 | 5/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 7/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 2/20 | 0.34 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.33 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL376772 | 0.85 | BACE1 (0.39) | CHEK1CHEK2AKT1PDE2APDE10A | |
| SCHEMBL376452 | 0.81 | MAPT (0.38) | CHEK1CHEK2AKT1PDE2APDE10A | |
| SCHEMBL375935 | 0.67 | FLT3 (0.53) | PDE2APDE10AFLT3BACE1 | |
| SCHEMBL30764823 | 0.65 | PDE2A (0.41) | PDE2APDE10AFLT3 | |
| SCHEMBL21617085 | 0.65 | PDE2A (0.41) | PDE2APDE10AFLT3 | |
| SCHEMBL9935890 | 0.64 | ACACB (0.50) | PDE2APDE10ACACNA1HACACBFLT3 | |
| SCHEMBL21447017 | 0.64 | ACACB (0.43) | CHEK1CHEK2AKT1PDE2APDE10A | |
| SCHEMBL15985609 | 0.63 | PDE2A (0.47) | CHEK1CHEK2AKT1PDE2APDE10A | |
| SCHEMBL7187755 | 0.63 | AGXT (0.47) | PDE2APDE10ANPC1RAB9AACACB | |
| SCHEMBL10283407 | 0.63 | PDE2A (0.42) | CHEK1CHEK2AKT1PDE2APDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2328890-B1 | 6 SUBSTITUTED 2-HETEROCYCLYLAMINO PYRAZINE COMPOUNDS AS CHK-1 INHIBITORS | PFIZER (US) | 2012-01-25 | — | — | EP | disclosed |
| WO-2010016005-A1 | 6 SUBSTITUTED 2-HETEROCYCLYLAMINO PYRAZINE COMPOUNDS AS CHK-1 INHIBITORS | PFIZER INC. (US) | 2010-02-11 | — | — | WO | disclosed |