Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 11/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 10/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10241632 | 0.86 | HCRTR2 (0.43) | HCRTR2HCRTR1KCNH2 | |
| SCHEMBL10241598 | 0.84 | HCRTR1 (0.35) | HCRTR2HCRTR1KCNH2LMNAPOLB | |
| SCHEMBL2618903 | 0.84 | HCRTR1 (0.61) | HCRTR2HCRTR1KCNH2 | |
| SCHEMBL10241209 | 0.82 | HCRTR2 (0.43) | HCRTR2HCRTR1KCNH2LMNA | |
| SCHEMBL10241618 | 0.82 | HCRTR1 (0.34) | HCRTR2HCRTR1 | |
| SCHEMBL10268894 | 0.81 | HCRTR1 (0.52) | HCRTR2HCRTR1KCNH2 | |
| SCHEMBL10241576 | 0.81 | HCRTR1 (0.47) | HCRTR2HCRTR1KCNH2TSHRLMNA | |
| SCHEMBL2619083 | 0.80 | HCRTR1 (0.53) | HCRTR2HCRTR1KCNH2 | |
| SCHEMBL2618611 | 0.79 | HCRTR1 (0.52) | HCRTR2HCRTR1KCNH2 | |
| SCHEMBL10189062 | 0.79 | HCRTR2 (0.70) | HCRTR2HCRTR1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120165339-A1 | CYCLOPROPANE DERIVATIVES | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2012-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165339-A1 | CYCLOPROPANE DERIVATIVES | HCRTR2, HCRTR1, CNR1 | HCRTR2 1/4885HCRTR1 2/4885KCNH2 1409/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.