Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1023574 | 0.86 | GRM5 (0.50) | GRM5KCNH2 | |
| SCHEMBL1021078 | 0.86 | GRM5 (0.53) | GRM5KCNH2 | |
| SCHEMBL1022517 | 0.83 | GRM5 (0.47) | GRM5KCNH2 | |
| SCHEMBL983538 | 0.80 | GRM5 (0.50) | GRM5KCNH2 | |
| SCHEMBL1020977 | 0.79 | GRM5 (0.63) | GRM5KCNH2 | |
| SCHEMBL1022668 | 0.79 | GRM5 (0.49) | GRM5KCNH2 | |
| SCHEMBL981007 | 0.77 | GRM5 (0.50) | GRM5KCNH2 | |
| SCHEMBL1021079 | 0.76 | GRM5 (0.50) | GRM5KCNH2 | |
| SCHEMBL1023063 | 0.76 | GRM5 (0.48) | GRM5KCNH2 | |
| SCHEMBL1023466 | 0.76 | GRM5 (0.51) | GRM5KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1670784-B1 | HETEROARYL-SUBSTITUTED IMDAZOLE DERIVATIVES AS GLUTAMATE RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2011-01-12 | — | — | EP | disclosed |
| US-7241760-B2 | Central nervous system disorders; psycholgical disorders; antiepi;eptic agents; schizophrenia; Alzheimer's disease; cognition activators; analgesics | HOFFMANN-LA ROCHE INC. (US) | 2007-07-10 | — | — | US | disclosed |
| US-20040254179-A1 | Heteroaryl-substituted imidazole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2004-12-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040254179-A1 | Heteroaryl-substituted imidazole derivatives | GRIN2A, GRIN2B, GRIK5 | GRM5 4/4885KCNH2 167/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.