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SCHEMBL10243467

SCHEMBL10243467

C=C(N)c1ccc(-c2ccc(-c3ccc(CN(C(=O)CN(C)S(=O)(=O)c4ccc(C)cc4)c4ccc(C(=O)O)c(O)c4)cc3)cc2)cc1

nearest known ligand 0.87

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ STAT3 P40763 20/20 0.87
▸ STAT5B P51692 6/20 0.87
▸ STAT1 P42224 5/20 0.87
▸ PTPN2 P17706 3/20 0.78
▸ PTPN1 P18031 3/20 0.78
▸ PTPRS Q13332 3/20 0.78

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10244955 0.93 STAT3 (1.00) STAT3STAT5BSTAT1PTPN2PTPN1
SCHEMBL15208565 0.93 STAT3 (1.00) STAT3STAT5BSTAT1PTPN2PTPN1
SCHEMBL10243331 0.92 STAT3 (0.88) STAT3STAT5BSTAT1PTPN2PTPN1
SCHEMBL10243794 0.92 STAT3 (0.88) STAT3STAT5BSTAT1PTPN2PTPN1
SCHEMBL15215014 0.92 STAT3 (0.88) STAT3STAT5BSTAT1PTPN2PTPN1
SCHEMBL15215003 0.91 STAT3 (0.85) STAT3STAT5BSTAT1PTPN2PTPN1
SCHEMBL15215012 0.91 STAT3 (0.85) STAT3STAT5BSTAT1PTPN2PTPN1
SCHEMBL10245129 0.90 STAT3 (0.84) STAT3STAT5BSTAT1PTPN2PTPN1
SCHEMBL10245138 0.88 STAT3 (1.00) STAT3STAT5BSTAT1PTPN2PTPN1
SCHEMBL10243334 0.88 STAT3 (1.00) STAT3STAT5BSTAT1PTPN2PTPN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012018868-A1 SUBSTITUTED 2-HYDROXY-4-(2-(PHENYLSULFONAMIDO)ACETAMIDO)BENZOIC ACID ANALOGS AS INHIBITORS OF STAT PROTEINS UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) 2012-02-09 — — WO disclosed