Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CETP | P11597 | 1/20 | 0.46 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.46 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.46 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | GUSB | P08236 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DAO | P14920 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10244350 | 1.00 | CETP (0.46) | CETPNR1I2SCN5APBRM1LMNA | |
| SCHEMBL532586 | 0.86 | CETP (0.48) | CETPNR1I2SCN5ADAO | |
| SCHEMBL531329 | 0.86 | CETP (0.48) | CETPNR1I2SCN5ADAO | |
| SCHEMBL531606 | 0.86 | CETP (0.48) | CETPNR1I2SCN5ADAO | |
| SCHEMBL531605 | 0.86 | CETP (0.48) | CETPNR1I2SCN5ADAO | |
| SCHEMBL531518 | 0.86 | CETP (0.48) | CETPNR1I2SCN5ADAO | |
| SCHEMBL531344 | 0.86 | CETP (0.48) | CETPNR1I2SCN5ADAO | |
| SCHEMBL4871404 | 0.83 | CETP (0.43) | CETPNR1I2SCN5AHTR2CMAPT | |
| SCHEMBL4871396 | 0.83 | CETP (0.43) | CETPNR1I2SCN5AHTR2CMAPT | |
| SCHEMBL4871394 | 0.83 | CETP (0.43) | CETPNR1I2SCN5AHTR2CMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2415759-A1 | CETP inhibitors | Merck Sharp & Dohme Corporation (US) | 2012-02-08 | — | — | EP | disclosed |