Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 11/20 | 0.70 |
| ▸ | JAK3 | P52333 | 7/20 | 0.66 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.59 |
| ▸ | JAK2 | O60674 | 4/20 | 0.57 |
| ▸ | JAK1 | P23458 | 4/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL913524 | 0.90 | JAK3 (0.61) | SYKJAK3MAPK8JAK2JAK1 | |
| SCHEMBL15452312 | 0.86 | SYK (0.66) | SYKJAK3JAK2JAK1 | |
| SCHEMBL913509 | 0.84 | JAK3 (0.60) | SYKJAK3MAPK8JAK2 | |
| SCHEMBL735463 | 0.82 | SYK (1.00) | SYK | |
| SCHEMBL3342288 | 0.82 | JAK3 (0.61) | SYKJAK3JAK2JAK1 | |
| SCHEMBL22261202 | 0.81 | JAK3 (0.79) | SYKJAK3JAK2JAK1 | |
| SCHEMBL10244516 | 0.80 | SYK (0.65) | SYKJAK3JAK2JAK1 | |
| SCHEMBL20844379 | 0.77 | JAK3 (0.73) | SYKJAK3JAK2JAK1 | |
| SCHEMBL10241924 | 0.77 | EGFR (0.73) | SYKMAPK8 | |
| SCHEMBL738205 | 0.76 | SYK (1.00) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138339-B2 | Inhibitors of protein kinases | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-03-20 | — | — | US | disclosed |
| US-20090318407-A1 | Inhibitors of protein kinases | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318407-A1 | Inhibitors of protein kinases | SYK, BTK, JAK1 | SYK 1/4885JAK3 7/4885MAPK8 420/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.