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Sugi Predict / Compounds / SCHEMBL10244636

SCHEMBL10244636

SCHEMBL10244636

Cc1ccc(S(=O)(=O)N(C)CC(=O)N(Cc2ccc(-c3cccc(N)c3)cc2)c2ccc(C(=O)O)c(O)c2)cc1

nearest known ligand 0.82

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ STAT3 P40763 19/20 0.82
▸ PTPN2 P17706 3/20 0.82
▸ PTPN1 P18031 3/20 0.82
▸ PTPRS Q13332 3/20 0.82
▸ STAT5B P51692 5/20 0.78
▸ STAT1 P42224 4/20 0.78

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15215008 0.93 STAT3 (0.83) STAT3PTPN2PTPN1PTPRSSTAT5B
SCHEMBL10245129 0.92 STAT3 (0.84) STAT3PTPN2PTPN1PTPRSSTAT5B
SCHEMBL15215014 0.91 STAT3 (0.88) STAT3PTPN2PTPN1PTPRSSTAT5B
SCHEMBL10245224 0.91 STAT3 (0.89) STAT3PTPN2PTPN1PTPRSSTAT5B
SCHEMBL10243181 0.90 STAT3 (1.00) STAT3PTPN2PTPN1PTPRSSTAT5B
SCHEMBL10246070 0.90 STAT3 (1.00) STAT3PTPN2PTPN1PTPRSSTAT5B
SCHEMBL15215004 0.89 STAT3 (0.87) STAT3PTPN2PTPN1PTPRSSTAT5B
SCHEMBL15215009 0.89 STAT3 (0.87) STAT3PTPN2PTPN1PTPRSSTAT5B
SCHEMBL10243331 0.88 STAT3 (0.88) STAT3PTPN2PTPN1PTPRSSTAT5B
SCHEMBL10243794 0.88 STAT3 (0.88) STAT3PTPN2PTPN1PTPRSSTAT5B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012018868-A1 SUBSTITUTED 2-HYDROXY-4-(2-(PHENYLSULFONAMIDO)ACETAMIDO)BENZOIC ACID ANALOGS AS INHIBITORS OF STAT PROTEINS UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) 2012-02-09 — — WO disclosed