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SCHEMBL10246434

SCHEMBL10246434

Cc1ccc(S(=O)(=O)N(C)CC(=O)N(Cc2ccc(C3CCN(C(=O)c4ccc(N)cc4)CC3)cc2)c2ccc(C(=O)OCc3ccccc3)c(OCc3ccccc3)c2)cc1

nearest known ligand 0.56

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ STAT3 P40763 20/20 0.56
▸ STAT5B P51692 4/20 0.55
▸ STAT1 P42224 3/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15208953 0.92 STAT3 (0.61) STAT3STAT5BSTAT1
SCHEMBL10243297 0.92 STAT3 (0.60) STAT3STAT5BSTAT1
SCHEMBL15208414 0.91 STAT3 (0.60) STAT3STAT5BSTAT1
SCHEMBL15209216 0.89 STAT3 (0.60) STAT3STAT5BSTAT1
SCHEMBL10246126 0.88 STAT3 (0.63) STAT3STAT5BSTAT1
SCHEMBL10244578 0.88 STAT3 (0.73) STAT3STAT5BSTAT1
SCHEMBL10243234 0.87 STAT3 (0.68) STAT3STAT5BSTAT1
SCHEMBL10244990 0.86 STAT3 (0.56) STAT3STAT5BSTAT1
SCHEMBL10244591 0.86 STAT3 (0.58) STAT3STAT5BSTAT1
SCHEMBL10243998 0.86 STAT3 (0.57) STAT3STAT5BSTAT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012018868-A1 SUBSTITUTED 2-HYDROXY-4-(2-(PHENYLSULFONAMIDO)ACETAMIDO)BENZOIC ACID ANALOGS AS INHIBITORS OF STAT PROTEINS UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) 2012-02-09 — — WO disclosed