Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 20/20 | 0.56 |
| ▸ | NTRK2 | Q16620 | 9/20 | 0.56 |
| ▸ | JAK2 | O60674 | 8/20 | 0.56 |
| ▸ | NTRK3 | Q16288 | 7/20 | 0.56 |
| ▸ | INSR | P06213 | 3/20 | 0.56 |
| ▸ | LYN | P07948 | 3/20 | 0.56 |
| ▸ | RET | P07949 | 3/20 | 0.56 |
| ▸ | MET | P08581 | 3/20 | 0.56 |
| ▸ | ROS1 | P08922 | 3/20 | 0.56 |
| ▸ | FGR | P09769 | 3/20 | 0.56 |
| ▸ | KIT | P10721 | 3/20 | 0.56 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.56 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.56 |
| ▸ | TIE1 | P35590 | 3/20 | 0.56 |
| ▸ | KDR | P35968 | 3/20 | 0.56 |
| ▸ | FLT3 | P36888 | 3/20 | 0.56 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.56 |
| ▸ | ABL1 | P00519 | 2/20 | 0.53 |
| ▸ | LCK | P06239 | 2/20 | 0.53 |
| ▸ | CSF1R | P07333 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL432086 | 0.90 | NTRK1 (0.60) | NTRK1NTRK2JAK2NTRK3INSR | |
| SCHEMBL431900 | 0.90 | NTRK1 (0.60) | NTRK1NTRK2JAK2NTRK3INSR | |
| SCHEMBL431229 | 0.88 | NTRK1 (0.64) | NTRK1NTRK2JAK2NTRK3INSR | |
| SCHEMBL433310 | 0.87 | NTRK1 (0.57) | NTRK1NTRK2JAK2NTRK3INSR | |
| SCHEMBL433343 | 0.87 | NTRK1 (0.58) | NTRK1NTRK2JAK2NTRK3INSR | |
| SCHEMBL433568 | 0.87 | NTRK1 (0.57) | NTRK1NTRK2JAK2NTRK3INSR | |
| SCHEMBL431111 | 0.87 | NTRK1 (0.57) | NTRK1NTRK2JAK2NTRK3INSR | |
| SCHEMBL464599 | 0.87 | NTRK1 (0.57) | NTRK1NTRK2JAK2NTRK3INSR | |
| SCHEMBL431071 | 0.87 | NTRK1 (0.61) | NTRK1NTRK2JAK2NTRK3INSR | |
| SCHEMBL431852 | 0.87 | NTRK1 (0.61) | NTRK1NTRK2JAK2NTRK3INSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012034091-A1 | IMIDAZO [1, 2] PYRIDAZIN COMPOUNDS AND COMPOSITIONS AS TRK INHIBITORS | IRM LLC (BM) | 2012-03-15 | — | — | WO | disclosed |