Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MELK | Q14680 | 2/20 | 0.40 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.39 |
| ▸ | ACSL1 | P33121 | 5/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.34 |
| ▸ | CHUK | O15111 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL167020 | 0.86 | HTR2B (0.45) | POLBSMN1; SMN2MELKAGPAT2ACSL1 | |
| SCHEMBL10249166 | 0.82 | SMN1; SMN2 (0.61) | POLBSMN1; SMN2AGPAT2ATMKDM4E | |
| SCHEMBL10248912 | 0.79 | SMN1; SMN2 (0.48) | POLBSMN1; SMN2AGPAT2ATMCYP11B1 | |
| SCHEMBL10249163 | 0.79 | SMN1; SMN2 (0.48) | POLBSMN1; SMN2AGPAT2ATMCYP11B1 | |
| SCHEMBL10248909 | 0.79 | SMN1; SMN2 (0.48) | POLBSMN1; SMN2AGPAT2ATMKDM4E | |
| SCHEMBL10249090 | 0.78 | SMN1; SMN2 (0.40) | POLBSMN1; SMN2AGPAT2ATMPRKACA | |
| SCHEMBL10249174 | 0.78 | SMN1; SMN2 (0.45) | POLBSMN1; SMN2AGPAT2ATMCYP11B1 | |
| SCHEMBL10248845 | 0.77 | SMN1; SMN2 (0.46) | POLBSMN1; SMN2AGPAT2ATMKDM4E | |
| SCHEMBL4399013 | 0.77 | SMN1; SMN2 (0.49) | POLBSMN1; SMN2AGPAT2ATMKDM4E | |
| SCHEMBL10249052 | 0.76 | MAPT (0.46) | POLBSMN1; SMN2AGPAT2ATMKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8461181-B2 | Fused heterocyclic compound and use thereof | SUMITOMO CHEMICAL COMPANY, LTD. (JP) | 2013-06-11 | — | — | US | disclosed |
| US-8273764-B2 | Fused heterocyclic compounds and use thereof | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2012-09-25 | — | — | US | disclosed |
| US-20120178779-A1 | FUSED HETEROCYCLIC COMPOUND AND USE THEREOF | SUMITOMO CHEMICAL COMPANY, LIMITED | 2012-07-12 | — | — | US | disclosed |
| US-20120015975-A1 | FUSED HETEROCYCLIC COMPOUND AND USE THEREOF | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2012-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120178779-A1 | FUSED HETEROCYCLIC COMPOUND AND USE THEREOF | C3AR1, C9, C5 | POLB 4724/4885SMN1; SMN2 1524/4885MELK 3443/4885 |
| US-20120015975-A1 | FUSED HETEROCYCLIC COMPOUND AND USE THEREOF | C3AR1, C9, C5 | POLB 4724/4885SMN1; SMN2 1524/4885MELK 3443/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.