⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1606195 | 0.88 | — | — | |
| SCHEMBL1605630 | 0.88 | NPSR1 (0.36) | — | |
| SCHEMBL1606126 | 0.88 | NPSR1 (0.36) | — | |
| SCHEMBL1606014 | 0.87 | — | — | |
| SCHEMBL14429519 | 0.83 | MAPK8 (0.34) | — | |
| SCHEMBL14429518 | 0.83 | MAPK8 (0.34) | — | |
| SCHEMBL5465000 | 0.83 | MAPK8 (0.34) | — | |
| SCHEMBL5465003 | 0.83 | MAPK8 (0.34) | — | |
| SCHEMBL14429542 | 0.83 | MAPK8 (0.34) | — | |
| SCHEMBL14429826 | 0.80 | NPSR1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120010256-A1 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | BIOVITRUM AB | 2012-01-12 | — | — | US | disclosed |
| US-20110082107-A1 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | AMGEN INC. | 2011-04-07 | — | — | US | disclosed |