Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 14/20 | 0.39 |
| ▸ | JAK3 | P52333 | 4/20 | 0.36 |
| ▸ | BTK | Q06187 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | ITK | Q08881 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10250618 | 0.91 | NTRK1 (0.38) | NTRK1JAK3BTKKDRITK | |
| SCHEMBL10252976 | 0.89 | NTRK1 (0.40) | NTRK1JAK3BTKKDRITK | |
| SCHEMBL2066044 | 0.88 | NTRK1 (0.42) | NTRK1JAK3BTKKDRITK | |
| SCHEMBL2066058 | 0.79 | NTRK1 (0.40) | NTRK1JAK3BTKKDRITK | |
| SCHEMBL14943961 | 0.78 | NTRK1 (0.42) | NTRK1JAK3BTKKDRITK | |
| SCHEMBL2066253 | 0.78 | NTRK1 (0.47) | NTRK1JAK3BTKKDRITK | |
| SCHEMBL2068382 | 0.77 | NTRK1 (0.44) | NTRK1JAK3BTKKDRITK | |
| SCHEMBL2066549 | 0.76 | NTRK1 (0.43) | NTRK1JAK3BTKKDRITK | |
| SCHEMBL2065973 | 0.75 | NTRK1 (0.44) | NTRK1JAK3BTKKDRITK | |
| SCHEMBL2066379 | 0.75 | NTRK1 (0.44) | NTRK1JAK3BTKKDRITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8148400-B2 | Thiazolyl compounds useful as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-04-03 | — | — | US | disclosed |
| US-20100048581-A1 | THIAZOLYL COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-02-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048581-A1 | THIAZOLYL COMPOUNDS USEFUL AS KINASE INHIBITORS | ERBB2, TEC, TTBK1 | NTRK1 327/4885JAK3 60/4885BTK 18/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.