Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 8/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 4/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL532792 | 0.77 | PARP1 (0.65) | PARP1HSD17B10MAPK1ALDH1A1ALOX15 | |
| SCHEMBL531880 | 0.73 | PARP1 (0.52) | PARP1HSD17B10MAPK1ALDH1A1ALOX15 | |
| SCHEMBL531431 | 0.68 | PARP1 (0.68) | PARP1HSD17B10MAPK1ALDH1A1ALOX15 | |
| SCHEMBL3431538 | 0.66 | AOC3 (0.59) | — | |
| SCHEMBL6296997 | 0.66 | CREBBP (0.57) | PARP1ALDH1A1BRD4CREBBP | |
| SCHEMBL532511 | 0.65 | PARP1 (0.61) | PARP1HSD17B10MAPK1ALDH1A1ALOX15 | |
| SCHEMBL10267633 | 0.65 | PARP1 (0.49) | PARP1HSD17B10MAPK1ALOX15HTT | |
| SCHEMBL531857 | 0.65 | PARP1 (0.63) | PARP1HSD17B10MAPK1ALOX15HTT | |
| SCHEMBL531589 | 0.65 | PARP1 (1.00) | PARP1 | |
| SCHEMBL1451025 | 0.64 | PARP1 (1.00) | PARP1HSD17B10MAPK1ALDH1A1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2415767-A1 | Poly (ADP-ribose) Polymerase (PARP) Inhibitors | Takeda Pharmaceutical Company Limited (JP) | 2012-02-08 | — | — | EP | disclosed |