Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.60 |
| ▸ | BRAF | P15056 | 13/20 | 0.54 |
| ▸ | RAF1 | P04049 | 12/20 | 0.54 |
| ▸ | HIPK4 | Q8NE63 | 3/20 | 0.54 |
| ▸ | PLK4 | O00444 | 2/20 | 0.54 |
| ▸ | AURKA | O14965 | 2/20 | 0.54 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.54 |
| ▸ | ABL1 | P00519 | 2/20 | 0.54 |
| ▸ | LCK | P06239 | 2/20 | 0.54 |
| ▸ | FYN | P06241 | 2/20 | 0.54 |
| ▸ | LYN | P07948 | 2/20 | 0.54 |
| ▸ | RET | P07949 | 2/20 | 0.54 |
| ▸ | SRC | P12931 | 2/20 | 0.54 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.54 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.54 |
| ▸ | AXL | P30530 | 2/20 | 0.54 |
| ▸ | FRK | P42685 | 2/20 | 0.54 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.54 |
| ▸ | BLK | P51451 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL545549 | 0.88 | KDR (0.62) | KDRBRAFRAF1HIPK4PLK4 | |
| SCHEMBL545538 | 0.85 | KDR (0.59) | KDRBRAFRAF1HIPK4PLK4 | |
| SCHEMBL546399 | 0.83 | KDR (0.56) | KDRBRAFRAF1HIPK4PLK4 | |
| SCHEMBL10199818 | 0.81 | DDR2 (0.55) | KDRBRAFRAF1HIPK4PLK4 | |
| SCHEMBL546211 | 0.81 | KDR (0.68) | KDRBRAFRAF1HIPK4PLK4 | |
| SCHEMBL5430598 | 0.80 | BRAF (0.68) | KDRBRAFRAF1HIPK4PLK4 | |
| SCHEMBL10199708 | 0.79 | RAF1 (0.74) | KDRBRAFRAF1HIPK4PLK4 | |
| SCHEMBL14684309 | 0.79 | KDR (0.81) | KDRBRAFRAF1HIPK4PLK4 | |
| SCHEMBL14684305 | 0.78 | KDR (0.83) | KDRBRAFRAF1HIPK4PLK4 | |
| SCHEMBL13547796 | 0.78 | BRAF (0.67) | KDRBRAFRAF1HIPK4PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110687-B2 | Bicyclic compounds with kinase inhibitory activity | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-02-07 | — | — | US | disclosed |