Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 15/20 | 0.53 |
| ▸ | RAF1 | P04049 | 13/20 | 0.53 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | FAAH | O00519 | 4/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL545697 | 0.88 | BRAF (0.58) | BRAFRAF1KDR | |
| SCHEMBL10262926 | 0.87 | BRAF (0.47) | BRAFRAF1KDR | |
| SCHEMBL545191 | 0.87 | BRAF (0.52) | BRAFRAF1KDR | |
| SCHEMBL545270 | 0.87 | BRAF (0.52) | BRAFRAF1KDR | |
| SCHEMBL545645 | 0.87 | BRAF (0.48) | BRAFRAF1KDRFAAH | |
| SCHEMBL546193 | 0.87 | BRAF (0.52) | BRAFRAF1KDR | |
| SCHEMBL14493297 | 0.83 | BRAF (0.64) | BRAFRAF1KDR | |
| SCHEMBL545766 | 0.82 | BRAF (0.58) | BRAFRAF1KDR | |
| SCHEMBL545179 | 0.82 | BRAF (0.70) | BRAFRAF1KDR | |
| SCHEMBL547123 | 0.82 | BRAF (0.70) | BRAFRAF1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110687-B2 | Bicyclic compounds with kinase inhibitory activity | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-02-07 | — | — | US | disclosed |