Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 4/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 6/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.35 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.34 |
| ▸ | PRKDC | P78527 | 3/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.33 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL609693 | 0.90 | BTK (0.42) | BTKPDE10AACVR1BACVRL1ACVR1 | |
| SCHEMBL18872617 | 0.89 | BTK (0.40) | BTKPDE10AHTR1AADRA1DADRA1A | |
| SCHEMBL10263468 | 0.85 | BTK (0.48) | BTKPDE10AHTR1AADRA1DADRA1A | |
| SCHEMBL10201997 | 0.84 | BTK (0.39) | BTKPDE10A | |
| SCHEMBL14696705 | 0.80 | BTK (0.40) | BTKPDE10APIK3CAPRKDC | |
| SCHEMBL19593954 | 0.78 | PPARA (0.42) | BTKPDE10A | |
| SCHEMBL607786 | 0.76 | BTK (0.48) | BTKPDE10A | |
| SCHEMBL16248091 | 0.75 | BTK (0.41) | BTKPDE10A | |
| SCHEMBL18872611 | 0.75 | BTK (0.36) | BTKPDE10A | |
| SCHEMBL610812 | 0.74 | BTK (0.39) | BTKPDE10AKAT2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120040949-A1 | Inhibitors of Bruton's Tyrosine Kinase | BERTHEL STEVEN JOSEPH (US) | 2012-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120040949-A1 | Inhibitors of Bruton's Tyrosine Kinase | BTK, SYK, LYN | BTK 1/4885PDE10A 867/4885HTR1A 3428/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.