Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 17/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10264902 | 0.93 | RAF1 (0.48) | RAF1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL10264745 | 0.86 | RAF1 (0.49) | RAF1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL324813 | 0.83 | NR1I2 (0.36) | RAF1 | |
| SCHEMBL10264797 | 0.82 | RAF1 (0.48) | RAF1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL10268700 | 0.81 | RAF1 (0.47) | RAF1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL326819 | 0.77 | NR1I2 (0.38) | RAF1 | |
| SCHEMBL326820 | 0.77 | NR1I2 (0.38) | RAF1 | |
| SCHEMBL326527 | 0.77 | NR1I2 (0.36) | RAF1 | |
| SCHEMBL15124008 | 0.77 | NR1I2 (0.36) | RAF1 | |
| SCHEMBL10264828 | 0.74 | NPSR1 (0.37) | RAF1MAPK14MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012006055-A2 | COMPOUNDS AND METHODS FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-01-12 | — | — | WO | disclosed |